Trepadone™ for the Medical Management of Joint Pain

Trepadone™ is a Medical Food formulated by practicing physicians to be used for the management and relief of pain and inflammation related to joint disorders. Trepadone™ is designed to influence the neurotransmitters that inhibit neuronal firing, reduce inflammation and stimulate the production of joint cartilage. Serotonin and GABA inhibit neuronal firing. Serine inhibits certain g-proteins of the opioid receptor resulting in activation of the opioid receptor. Chondrotin sulfate and glucosamine supply the building blocks for joint cartilage repair. At low dose nitric oxide inhibits pain by activation of nNOS. Trepadone™ provides L-arginine at low dose along with L-glutamine to activate the NMDA and opioid receptors. L-histidine produces brain histamine that promotes production of naturally occurring glucocorticoids. Omega-3-FFAs cause prostaglandin- lowering effects by blocking the production of arachidonic acid. Glucocorticoids inhibit inflammation by blocking the production of the prostaglandins, including both prostacyclines and thromboxanes. The action of the glucocorticoids is synergistic with nitric oxide pathways. Thus, Trepadone™ can effectively reduce inflammation and act synergistically with ASA and NSAIDs.

Nutritional Deficiency Associated with Pain Syndromes and Joint Disorders

Pain disorders are associated with a deficiency of nitric oxide, GABA, serotonin and prostaglandin precursors. Joint disorders are associated with a deficiency of chondrotin sulfate and glucosamine. Pain is also associated with insensitivity to circulating GABA.

Trepadone™ Ingredients: L-Arginine, L-Histidine, L-Glutamine, L-Serine, GABA, Griffonia Seed (20% 5HTP), Whey Protein, Grape Seed Extract, Chondrotin Sulfate, Glucosamine, Omega-3-FFA from Tuna oil and Cocoa. Supplied in 60 capsule bottles. 12 bottles per case. NDC # 68405-1016-03

Why Is Trepadone™ Prescribed?

Trepadone™ is a Medical Food used to manage pain and inflammation.

Trepadone™ provides the nutrients required by the brain to reduce pain and decrease inflammation and to stimulate the production of joint cartilage. Trepadone™ is used as part of a program to manage the symptoms of osteoarthritis.

Trepadone™ is used to reduce pain and inflammation in joint. Although the benefits of Trepadone™ will occur in the first few doses, the effects will improve over the first 60 days of use. Trepadone™ does not contain drugs and has no risk of overdose.

Trepadone™ is not addictive.

Do not take Trepadone™ with food!

Trepadone™ should be taken with water on an empty stomach at least 30 minutes before or after eating.

Take two (2) capsules every four hours or as needed under medical supervision.

Trepadone™ can be taken with prescription medications under medical supervision.

Side Effects: The side effect profile of Trepadone™ is comparable to the rate of food intolerance in the community. The ingredients in Trepadone™ are derived from nutrient based compounds found in the normal food chain. Food intolerance is an adverse reaction to food that does not involve the body's immune system. When first starting any amino acid therapy, some people complain of mild headaches, stomach upset, and nausea or mouth dryness. These symptoms are mild and temporary and can be managed by drinking plenty of fluids and carefully titrating the dose. These side effects are relieved by lowering the dose. Trepadone™ should not be taken by patients who are receiving MAO inhibitors.