Novel Nitric Oxide Metabolite as a Preventative Measure
by David Hiller
In around six years’ time, it’s estimated that one in six people will be over 60. In the decade between 2020 and 2050, the share of the global population over 60 will double from 1 billion to 2.1 billion, says the World Health Organization (WHO). The cost of healthcare is increasing at double the rate of global economic growth.
By 2040, the world will be collectively spending an estimated $25 trillion every year on healthcare, representing a 150% increase compared with 2014, according to a study published in The Lancet.
On a global basis, the majority of caregivers are unpaid and would be worth the equivalent of around $11 trillion in global GDP, according to the International Labour Organization (ILO), if it were valued on an hourly minimum wage.
The components of how the ILO arrived at this number are as follows:
• Cardiovascular Diseases (CVD): Approximately 523 million cases globally.
• Type 2 Diabetes: Around 537 million adults worldwide as of 2021.
• Neurodegenerative Diseases (e.g., Alzheimer’s Disease): Over 55 million people globally.
• Erectile Dysfunction (ED): Affects about 322 million men projected by 2025.
• Chronic Kidney Disease: Approximately 700 million people worldwide.
• Metabolic Syndrome: Estimated to affect about 25% of the global population.
• Immune System Decline: Common in aging populations, affecting millions.
Potential Patient Population
Considering the overlap and focusing on adults aged 50 and above (a group significantly
affected by NO decline):
• Global Population Aged 50+: Approximately 1.8 billion people.
• Assumed Percentage Benefiting from NO Supplementation: 30%.
• Potential Patient Population: 1.8 billion x 30% = 540 million individuals.
What would be the economic impact on health care with a patented Nitric Oxide metabolite that restores Nitric Oxide homeostasis?
The introduction of a technology that restores nitric oxide (NO) homeostasis through the creation of a metabolite could have profound economic implications for the healthcare industry. Nitric oxide is a crucial signaling molecule involved in various physiological processes, including vasodilation, neurotransmission, and immune response.
Imbalances in NO levels are associated with numerous health conditions such as cardiovascular diseases, hypertension, erectile dysfunction, and metabolic disorders. Restoring NO homeostasis could, therefore, offer therapeutic benefits across a wide spectrum of diseases, leading to significant economic impacts.